Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma.

• Tác giả: Jeremy Abramson, Govind Bhagat, Weina Chen, April Chiu, William Choi, Karen Dybkaer, Andrés Ferreri, Heounjeong Go, Eric Hsi, Youchao Jia, Jianyong Li, Ling Li, Yong Li, Mark Long, Everardo Macias, Yi Miao, Michael Møller, Santiago Montes-Moreno, Zenggang Pan, Ben Parsons, Anamarija Perry, Maurilio Ponzoni, Wen-Yu Shi, Wen Shuai, Aliyah Sohani, Alexandar Tzankov, J Han van Krieken, Carlo Visco, Bangchen Wang, Shi Wang, Xiaoxiao Wang, Yafei Wang, Henry Withers, Bing Xu, Mina Xu, Zijun Xu-Monette, Ken Young, Alyssa Yuan, Qiongli Zhai, Fenghuang Zhan, Shanxiang Zhang, Youli Zu
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Research square , 2025
• Bộ sưu tập: NCBI
• ID: 218616

Tóm tắt

Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive lymphoma with molecular heterogeneity not well characterize. In this study, we performed next-generation sequencing analysis for a large number of DNA and RNA samples from patients with PT-DLBCL. DNA sequencing analysis identified ≥ 3 chromosomes with copy number variations (CNVs) and microsatellite instability as prognostic biomarkers, rather than