Lipid-protecting disulfide bridges are the missing molecular link between ApoE4 and sporadic Alzheimer's disease in humans.

• Tác giả: Roy G Cutler, Gregory S Keyes, Xiufeng Li, Christopher E Ramsden
• Ngôn ngữ: eng
• Ký hiệu phân loại: 549.32 Sulfides, antimonides, arsenides, selenides, tellurides
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 218635

Tóm tắt

As the principal lipid transporter in the human brain, apolipoprotein E (ApoE) is tasked with the transport and protection of highly vulnerable lipids required to support and remodel neuronal membranes, in a process that is dependent on ApoE receptors. Human