Generation, establishment and characterization of three pluripotent stem cell lines (CVTTHi002-A, CVTTHi003-A and CVTTHi004-A) from primary testicular somatic cells isolated from two prepuberal and one peripuberal Klinefelter Syndrome (47 XXY) patients.

• Tác giả: Juan Anguita, Ana María Aransay, Beatriz Barreña, Andrea Sáez de Cámara, Cristina Eguizabal, Lara Herrera, Myriam Martin-Inaraja, Roberto Matorras, Ainhoa Palacios, María Begoña Prieto, Irene Romayor, Silvia Santos, Estíbaliz Solorzano, Miguel Ángel Vesga, Maria Villaverde
• Ngôn ngữ: eng
• Ký hiệu phân loại: 020.601 International organizations
• Thông tin xuất bản: England : Stem cell research , 2025
• Bộ sưu tập: NCBI
• ID: 218721

Tóm tắt

Klinefelter Syndrome (KS) is an aneuploid genetic condition in males characterized by at least one additional copy of the X chromosome. Due to fibrotic degeneration of the testis, these patients suffer infertility in the future. The pathogenic mechanism by which this occurs is still not well known. Here, we establish three Induced Pluripotent Stem cell (iPSC) lines derived from prepuberal and peripuberal KS patient's testicular somatic cells. These could be the first steps towards the creation of an in vitro platform to analyze the molecular mechanisms underlying pathophysiology of the testes in KS patients.