Matrix metalloproteinase-responsive melanin nanoparticles utilize live neutrophils for targeted high-risk plaque detection and atherosclerosis regression.

• Tác giả: Wenwen Cai, Bo Fan, Jie Hong, Nan Hu, Weiguang Shen, Qian Wu, Yang Xing, Juan Zhang, Ruiping Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Acta biomaterialia , 2025
• Bộ sưu tập: NCBI
• ID: 219026

Tóm tắt

Abrupt rupture of atherosclerotic plaque is the predominant contributor to acute cardiovascular events. It is of clinical importance to effectively identify and inhibit high-risk plaque progression. However, this remains a major challenge due to the inadequate targeting of theranostic agents to atherosclerotic lesions. Herein, we utilize live neutrophils to encapsulate melanin-based theranostics (termed MNP