Endothelin receptor antagonists in chronic kidney disease.

• Tác giả: Neeraj Dhaun, Hiddo J L Heerspink, Donald E Kohan, Adrian Liew, Irene L Noronha, J David Smeijer
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature reviews. Nephrology , 2025
• Bộ sưu tập: NCBI
• ID: 219237

Tóm tắt

Endothelin-1 is a potent vasoconstrictor that has diverse physiological functions in the kidney, including in the regulation of blood flow and glomerular filtration, electrolyte homeostasis and endothelial function. Overexpression of endothelin-1 contributes to the pathophysiology of both diabetic and non-diabetic chronic kidney disease (CKD). Selective endothelin receptor antagonists (ERAs) that target the endothelin A (ET