Calcified neurocysticercosis, the final stage of the disease, was until recently regarded as residual inactive scarring, with no clinical relevance in most cases. However, episodes of inflammatory reaction around calcifications associated with clinical symptoms have recently been described. We report here the 20-year radiological follow-up of a patient presenting 16 calcifications with multiple episodes of asynchronous inflammatory phenomena around several of them, not always associated with clinical symptomatology. This case is unique, showing the possibility of chronicity of this phenomenon, and the need to better understand the factors involved in determining the best management.