Synthesis of Diastereomeric Hydrobenzofurans and Hydronaphthofurans via an Iodine Reagent-Promoted Intramolecular Dearomatization Reaction.

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Tác giả: Xinkun An, Guoen Cui, Xie He, Haoyun Ma, Mingan Wang, Tingting Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 271.6 *Passionists and Redemptorists

Thông tin xuất bản: United States : The Journal of organic chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 219762

The first metal- and base-free construction of diastereomeric hydrobenzofurans and hydronaphthofurans, which were capable of further transformations to achieve natural product frameworks, was achieved by the intramolecular oxidized dearomatization of phenol or naphthol derivatives via the promotion of iodine reagents. Enantioselective products were obtained through chiral substrates or iodine catalysts. This step-economical protocol built multiple chiral centers with extensive tolerance of various substrates, which resulted in a potential molecular library for developing functional polycyclic scaffolds.
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