Thiolated gellan gum/polyethylene glycol diacrylate hydrogels containing timolol maleate-loaded chitosan nanoparticles for ophthalmic delivery.

• Tác giả: Nazanin Amiryaghoubi, Hamid Erfan-Niya, Marziyeh Fathi, Golnaz Shajari
• Ngôn ngữ: eng
• Ký hiệu phân loại: 583.625 *Violates
• Thông tin xuất bản: England : Biomedical materials (Bristol, England) , 2025
• Bộ sưu tập: NCBI
• ID: 219771

Tóm tắt

The combination of hydrogels with nanoformulations can significantly enhance the delivery and effectiveness of drugs in ophthalmic drug delivery systems. In the current study, the polyethylene glycol diacrylate (PEGDA)/thiolated gellan gum (GGSH) hydrogels based on GGSH and PEGDA were prepared via thiol-ene reaction using Irgacure 2959 as a photoinitiator. To this end, the modification of GG was achieved by esterification of the hydroxyl groups of GG with the carboxyl group of mercaptopropionic acid with a free thiol amount of 95.5 μmol g