Catalytic Enantioselective [4+1]-Annulation of Carboxylic Acids with Cyclopropenes.

• Tác giả: Pazhamalai Anbarasan, Marimuthu Bakkiyaraj
• Ngôn ngữ: eng
• Ký hiệu phân loại: 661.86 *Acids
• Thông tin xuất bản: United States : Organic letters , 2025
• Bộ sưu tập: NCBI
• ID: 219796

Tóm tắt

An efficient asymmetric synthesis of 3-vinylphthalides has been accomplished through rhodium-catalyzed [4+1]-annulation of arylcarboxylic acids with cyclopropenes involving C-H bond functionalization. The method exhibited excellent compatibility for various functional groups and offered diverse substituted 3-vinylphthalides in excellent yield and enantioselectivity. Synthetic application and control experiments were also performed to demonstrate the utility and understand the reaction pathway.