Synthesis of Indoles through C2-C3 Bond Formation Using Lawesson's Reagent.

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Tác giả: Mohan Bhadbhade, David StC Black, Yao Cheng, Naresh Kumar, Tsz Tin Yu

Ngôn ngữ: eng

Ký hiệu phân loại: 618.0835 Other branches of medicine Gynecology and obstetrics

Thông tin xuất bản: United States : The Journal of organic chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 220059

Amidophenylglyoxylic esters react with Lawesson's reagent at elevated temperatures, leading to the formation of a diverse array of indole derivatives. This methodology demonstrates broad substrate tolerance and utilizes readily available starting materials. Moreover, this synthetic route is metal-free and environmentally compatible. The scalability of this approach is evidenced by successful gram-scale reactions, highlighting its potential industrial applicability. Furthermore, the resulting products are amenable to further modifications, thereby expanding the potential applications of this synthetic strategy.
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