BACKGROUND: With the popularization of laser therapy, an increasing number of patients are undergoing fractional CO AIMS: This study aimed to examine the clinical efficacy of moist wound healing after fractional CO PATIENTS/METHODS: A total of 15 individuals volunteered to undergo fractional CO RESULTS: The observation and control groups received different nursing interventions. The time to regression of erythema and swelling was significantly shorter in the observation group than in the control group. In addition, the scab formed at the wound site was thinner, and shedding was faster in the observation group than in the control group. The Clinical Erythema Assessment score of the observation group was significantly lower than that of the control group (p <
0.05). The wound healing time was 5.73 ± 0.70 days in the observation group and 7.73 ± 0.72 days in the control group, with the difference being statistically significant (p <
0.05). After 30 min and 12 h of nursing intervention, the Visual Analog Scale score of the observation group was significantly lower than that of the control group (p <
0.05). However, after 24 h of treatment, neither group showed significant pain. Both groups showed varying degrees of acne, pustules, and exudation, which subsided within 7 days. Furthermore, the control group had 2 cases of mild pigmentation, which resolved within 3 months. Neither group experienced adverse reactions such as skin infection, depigmentation, or scar formation. CONCLUSION: Moist healing therapy can accelerate wound healing and reduce the duration of erythema and edema after fractional CO