Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson's disease.

• Tác giả: Shi-Dong Chen, Shu-Fen Chen, Yi-Lin Chen, Mei Cui, Yi-Wei Feng, Yu Guo, Si-Da Han, Wei-Dong Le, Jia-Yi Li, Wen-Sheng Li, Cong Liu, Yi-Qi Liu, Bo-Xun Lu, Ling-Zhi Ma, You-Sheng Shu, Jian Wang, Ting-Ting Wang, Bang-Sheng Wu, Kai-Min Wu, Yu-Jie Xiao, Qian-Hui Xu, Liu Yang, Zhao-Fei Yang, Keqiang Ye, Jin-Tai Yu, Peng Yuan, Ya-Ru Zhang, Yi Zhang, Jue Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.746 Data compression
• Thông tin xuất bản: United States : Science (New York, N.Y.) , 2025
• Bộ sưu tập: NCBI
• ID: 220307

Tóm tắt

Neuronal accumulation and spread of pathological α-synuclein (α-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying the uptake of α-syn fibrils remain unclear. In this work, we identified