New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation.

• Tác giả: Robert Andrianne, David W Barham, Arthur L Burnett, Chrystal Chang, Zafardjan Dalimov, Kelli Gross, Martin S Gross, Muhammed Hammad, Georgios Hatzichristodoulou, James Hotaling, Tung-Chin Hsieh, Adam Jones, James M Jones, Aaron Lentz, Jake Miller, Vaibhav Modgil, Daniar Osmonov, Sung Hun Park, Ian Pearce, Paul Perito, Hossein Sadeghi-Nejad, Maxime Sempels, Jay Simhan, Alfredo Suarez-Sarmiento, Daniel Swerdloff, Koenraad van Renterghem, Jonathan N Warner, Faysal A Yafi, Matthew Ziegelmann
• Ngôn ngữ: eng
• Thông tin xuất bản: England : BJU international , 2025
• Bộ sưu tập: NCBI
• ID: 220346

Tóm tắt

 OBJECTIVES: To evaluate the pre- and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized. PATIENTS AND METHODS: We retrospectively reviewed a 16-centre multi-institutional database of IPP surgeries performed by experienced implanters from 2016 to 2021. Poor corporal integrity (PCI) was defined as intraoperative (iPCI) corporal complications or postoperative (pPCI) corporal complications. Multivariable analysis was performed to identify independent predictors of PCI, iPCI, and pPCI. Primary outcomes included intra- and postoperative corporal complications. RESULTS: We identified 5153 patients for analysis from 5406 IPP cases, finding 152 (2.95%) cases of PCI. On multivariable analysis, predictors of PCI included revision IPP surgery (odds ratio [OR] 8.16, 95% confidence interval [CI] 5.15-12.92
  P <
  0.001), sequential dilatation (OR 2.12, 95% CI 1.32-3.39
  P = 0.002), coronary artery disease (CAD)/peripheral vascular disease (PVD) (OR 1.81, 95% CI 1.18-2.77
  P = 0.006), older age (OR 1.02, 95% CI 1.01-1.04
  P = 0.013), and corporal scarring (OR 1.58, 95% CI 1.0-2.5
  P = 0.049). Predictors of iPCI included revision IPP surgery (OR 7.34, 95% CI 4.18-12.88
  P <
  0.001), corporal scarring (OR 2.77, 95% CI 1.64-4.69
  P <
  0.001), radiation therapy (OR 2.25, 95% CI 1.0-5.04
  P = 0.049), and older age (OR 1.03, 95% CI 1.0-1.05
  P = 0.025). Revision IPP surgery (OR 7.92, 95% CI 3.69-17.01
  P <
  0.001), sequential dilatation (OR 3.4, 95% CI 1.61-7.19
  P = 0.001), CAD/PVD (OR 2.98, 95% CI 1.56-5.72
  P = 0.001), and history of priapism (OR 3.59, 95% CI 1.08-11.99
  P = 0.038) were predictive of pPCI. CONCLUSION: Coronary artery disease/PVD, being of older age, having corporal scarring, undergoing IPP revision surgery and sequential dilatation were predictive risk factors for complications associated with PCI. Identifying patients who are at risk of having PCI may improve patient-specific counselling, consideration of referral to more experienced implanters, and surgical planning to potentially promote longer-term device viability.