Biomedical Engineering on Smart Polymeric Nanoparticle-Hydrogel Platforms for Efficient Antibiotic Delivery against Bacterial-Infected Wounds.

• Tác giả: Kefurong Deng, Enyu Dong, Wensheng Gong, Xingyu Jiang, Yachao Li, Yusheng Xiao, Jiahao Xu, Shuo Xu, Xianghui Xu, Yini Xu, Zenan Zeng, Dongzhe Zou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.822 Coal
• Thông tin xuất bản: United States : ACS biomaterials science & engineering , 2025
• Bộ sưu tập: NCBI
• ID: 220447

Tóm tắt

The rising incidence of bacterial infections poses a significant challenge to global public health. The development of safe and effective antibacterial treatment strategies is an urgent need in the field of biomedicine. In this work, we developed a smart nanoparticle-hydrogel platform to address bacterial infections in wounds. Rifampicin-loaded chitosan-functionalized nanoparticles (R-CNP) could break bacterial barriers and enhance antibiotic internalization. R-CNP reduced the minimum inhibitory concentration of rifampicin against