Discovery of a novel Wnt inhibitor DK419: Reversing temozolomide resistance in glioblastoma by switching off Wnt/β-catenin signaling pathway to inhibit MGMT expression.

• Tác giả: Peiying Bai, Ting Ren, Guohui Sun, Qing Tang, Peng Wang, Na Zhang, Lijiao Zhao, Rugang Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.3177 Bibliographic analysis and control
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 220728

Tóm tắt

Temozolomide (TMZ) remains the primary oral chemotherapeutic agent for glioblastoma, but its efficacy is hampered by resistance mechanisms involving O