BACKGROUND AND OBJECTIVE: Type 2 diabetes (T2D) is a prevalent disease characterized by insulin resistance (IR), leading to energy disruptions in myocardial cells and increasing cardiovascular (CV) risk. Current diagnostic methods are either systemic, thus lacking tissue-specific information, or invasive. The hyperinsulinemic euglycemic clamp (HEC) combined with [ METHODS: The study included forty-two patients with T2D who enrolled in a clinical trial (NCT02248311) and who underwent biochemical analyses, anthropometric measurements and [ RESULTS: MIRA was developed as a myocardial IR estimator (R CONCLUSIONS: We hereby present MIRA, a myocardial IR calculation app to manage myocardial-specific affectation in T2D, as well as to provide with patient phenotyping and CV risk assessment.