Antiviral signaling of a type III CRISPR-associated deaminase.

• Tác giả: Meirong Chen, Yijun Chen, Yurong Cui, Yan Duan, Chunyi Hu, Chenyang Hua, Shunli Ji, Jianping Kong, Guanglei Li, Shunxiang Li, Yutao Li, Zhaoxing Li, Meiling Lu, Wanqian Wu, Yibei Xiao, Purui Yan, Peng Yang, Yucheng Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 943.1087 *Northeastern Germany
• Thông tin xuất bản: United States : Science (New York, N.Y.) , 2025
• Bộ sưu tập: NCBI
• ID: 221119

Tóm tắt

Prokaryotes have evolved diverse defense strategies against viral infection, including foreign nucleic acid degradation by CRISPR-Cas systems and DNA and RNA synthesis inhibition through nucleotide pool depletion. Here, we report an antiviral mechanism of type III CRISPR-Cas-regulated adenosine triphosphate (ATP) depletion in which ATP is converted into inosine triphosphate (ITP) by CRISPR-Cas-associated adenosine deaminase (CAAD) upon activation by either cA