Background: Coronary artery disease is common in older men, is one of the leading causes of fatal and hospitalization. Currently, there are many treatments to reduce the vascular events in these patients including anti-platelet aggregation aspirin. Objectives: To determine the rate of aspirin resistance in patients with coronary artery disease are using aspirin and explore the relationship between aspirin resistance ratio with some clinical features of coronary artery disease. Patients and methods: Cross-sectional descriptive prospective study. Studies of platelet aggregation with the two substances is ADP (concentration of 10uM/l) and arachidonic acid (concentration of 0.5mg/ml), on 71 patients with coronary artery disease using aspirin. Assessment of aspirin resistance according to Gum P.A. (2001): aspirin resistance is completely when 0.5mg/ml arachidonic acid caused platelet aggregation or = 20 percent and 10uM/l ADP causes platelet aggregation or = 70 percent
resistance aspirin is not completely when had one of the two above criteria. Results and conclusions: The rate of aspirin resistance (complete resistance or incomplete resistance) of patients with coronary artery disease was 67.6 percent
the ratio of complete aspirin-resistant patients is 32.4 percent and the rate of incomplete aspirin-resistance is 35.2 percent. No differences were statistically significant between the 2 groups of patients resistant to aspirin and aspirin-sensitive patients in the number of risk factors for coronary artery disease, age, sex and platelet count (p 0, 05). The amount of hemoglobin in the aspirin-resistant group tends to be lower than those sensitive to aspirin, but this difference was not statistically significant (p = 0.1).