Cobalt carbonate nanorods enhance chemotherapy via neutralization of acidic tumor microenvironment and generation of carbonate radical anions for necrosis.

• Tác giả: Bing Liang, Jingjing Liu, Benmeng Wu, Min Wu, Lu Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 355.1294 Military life and customs
• Thông tin xuất bản: Netherlands : Colloids and surfaces. B, Biointerfaces , 2025
• Bộ sưu tập: NCBI
• ID: 222878

Tóm tắt

One of the hallmarks of cancer is the acidic extracellular space surrounding the tumor, which is linked to metabolic reprogramming and the use of glycolysis. Additionally, the acidic tumor microenvironment (TME) establishes a physiological barrier called "ion trapping" and significantly lowers the ability of cells to absorb weak-base chemotherapy agents. Although CO