Nature-inspired synthesis of metal nanoparticles (MNP) has long been a topic of interest among the researcher community. Herein, we report the synthesis of anisotropic Silver nanoparticles (AgNPs) and Gold nanoparticles (AuNPs) by Bombax Ceiba (B.C.) leaf extract. The crystal structure of the synthesized MNPs were thoroughly analyzed by various characterization techniques as UV-Vis, XRD, TEM, DLS, and Zeta potential. The chemical composition of the B.C. leaf extract was analysed by HR-LCMS and IR spectroscopy. The biogenic synthesized anisotropic AgNPs and AuNPs shows good anticancer activity against HIO180 and HeyA8 cells. The IC