A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2

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Tác giả: Angel Morales-Gonzalez, Eduardo Osiris Madrigal-Santillan, Jose Antonio Morales-Gonzalez

Ngôn ngữ: eng

ISBN-13: 978-9535128373

Ký hiệu phân loại: 821.91 English poetry

Thông tin xuất bản: IntechOpen, 2016

Mô tả vật lý: 1 electronic resource (210 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 223334

 Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes
  knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
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