The development of mathematical techniques, combined with new possibilities of computational simulation, have greatly broadened the study of non-linear lattices, a theme among the most refined and interdisciplinary-oriented in the field of mathematical physics. This Special Issue mainly focuses on state-of-the-art advancements concerning the many facets of non-linear lattices, from the theoretical ones to more applied ones. The non-linear and discrete systems play a key role in all ranges of physical experience, from macrophenomena to condensed matter, up to some models of space discrete space-time.