Single-Domain Antibodies: Biology, Engineering and Emerging Applications

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Tác giả: C. Roger MacKenzie, Kevin A. Henry

Ngôn ngữ: eng

ISBN-13: 978-2889454327

Ký hiệu phân loại:

Thông tin xuất bản: Frontiers Media SA, 2018

Mô tả vật lý: 1 electronic resource (338 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 223792

Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.
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