Metastatic Progression and Tumour Heterogeneity

• Tác giả: Fred Hollande, Delphine Merino
• Ngôn ngữ: eng
• ISBN-13: 978-3039288533
• Thông tin xuất bản: Basel, Switzerland : MDPI - Multidisciplinary Digital Publishing Institute, 2020
• Mô tả vật lý: 1 electronic resource (312 p.)
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 225026
• Chủ đề: 1. Medicine

Tóm tắt

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.