Chapter Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10

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Tác giả: Ilan Attali, Shay Ben-Aroya, Tal Keren-Kaplan, Oded Kleifeld, Olga Levin-Kravets, Gali Prag

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: InTechOpen, 2019

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Bộ sưu tập: Tài liệu truy cập mở

ID: 225304

Ubiquitylation is a posttranslational modification that determines protein fate. The ubiquitin code is written by enzymatic cascades of E1 and E2 and E3 enzymes. Ubiquitylation can be edited or erased by deubiquitylating enzymes. Ub-receptors are proteins that read and decipher the ubiquitin codes into cellular response. They harbor a ubiquitin-binding domain and a response element. Interestingly, Ub-receptors are also regulated by ubiquitylation and deubiquitylation. However, until recently, the molecular details and the significance of this regulation remained enigmatic. Rpn10 is a Ub-receptor that shuttles ubiquitylated targets to the proteasome for degradation. Here we review recent data on Rpn10, with emphasis on its regulation by ubiquitylation.
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