IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation.

• Tác giả: I Berest, M Kopf, F Piattini, N D Sidiropoulos
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Mucosal immunology , 2025
• Bộ sưu tập: NCBI
• ID: 225483

Tóm tắt

Influenza virus infection is a leading cause of morbidity and mortality worldwide, posing a significant public health problem. The pro-inflammatory cytokine interleukin-6 (IL-6) has been shown to promote defense against respiratory viral infection, while excessive IL-6 responses have been associated with severe pneumonia. Heterogenous expression of IL-6R and the IL-6-signal transducer subunit (gp130) across many cell types and different signaling modalities have made it difficult to define the precise role of the IL-6/IL-6R pathway in vivo. We generated multiple cell lineage-specific Il6ra-deficient mice and compared them to global Il6ra