Detection and neural encoding of whisker-generated sounds in mice.

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Tác giả: Ben Efron, Yonatan Katz, Ilan Lampl, Athanasios Ntelezos

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Current biology : CB , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 226426

The vibrissa system of mice and other rodents enables active sensing via whisker movements and is traditionally considered a purely tactile system. Here, we ask whether whisking against objects produces audible sounds and whether mice are capable of perceiving these sounds. We found that whisking by head-fixed mice against objects produces audible sounds well within their hearing range. We recorded neural activity in the auditory cortex of mice in which we had abolished vibrissae tactile sensation and found that the firing rate of auditory neurons was strongly modulated by whisking against objects. Furthermore, the object's identity could be reliably decoded from the population's neuronal activity and closely matched the decoding patterns derived from sounds that were recorded simultaneously, suggesting that neuronal activity reflects acoustic information. Lastly, trained mice, in which vibrissae tactile sensation was abolished, were able to accurately identify objects solely based on the sounds produced during whisking. Our results suggest that, beyond its traditional role as a tactile sensory system, the vibrissa system of rodents engages both tactile and auditory modalities in a multimodal manner during active exploration.
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