CT coronary angiography is the most reliable non-invasive imaging technique for ruling out coronary artery disease. However, its specificity is not high. Thus, when coronary stenosis of uncertain functional significance is detected, the recommendation is to perform complementary imaging tests to assess myocardial ischemia. CT myocardial perfusion imaging and CT fractional flow reserve provide added diagnostic accuracy and prognostic value to CT coronary angiography, by increasing its predictive value and facilitating therapeutic decision-making.