Delayed healing of wounds in diabetics is mainly due to tissue inflammation, poor vasculature, lack of neovascularization, and bacterial infection. Therefore, a therapeutic protocol that disrupts this cycle and speeds healing is urgently needed. Despite attempts to enhance wound dressing effectiveness through hydrogels with diverse complexes such as bacterial cellulose (BC) combined with chitosan, BC/ chitosan/hyaluronic acid, and BC/chitosan/collagen, the toughness and adhesion properties of hydrogel remain constrained, leading to inadequate and uncontrollable wound healing. To address the challenge, we have devised an innovative solution by integrating barnacle cement protein (cp19k) and spider silk protein (major ampullate spidroin 1, MaSp1) into a BC matrix, complemented by chitosan. This development has led to the creation of a novel BC-based composite hydrogel BC/cp19k-MaSp1/C