pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation.

• Tác giả: Houda Gui, Yongzhe Liu, Baojin Ma, Xiaoni Ma, Ziwei Wang, Xin Xu, Longxuan Zhan, Xi Zhang, Hongxia Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Carbohydrate polymers , 2025
• Bộ sưu tập: NCBI
• ID: 226760

Tóm tắt

Infected wound healing is a global medical challenge due to persistent bacterial infection and excess inflammation. Designing microenvironment-responsive and self-adaptive hydrogels with antibacterial and anti-inflammatory properties is expected to be an effective strategy to promote infected wound healing. In this study, a self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel (SCSC) for pH-responsive release of curcumin has been prepared at room temperature by simple stirring. The incorporation of the crosslinker, Sr