OBJECTIVE: Cesarean delivery is the most common major operating room procedure performed in the United States. Wound closure after cesarean delivery includes suturing for uterine closure and to close the fascial-and sometimes subcutaneous-tissue layer followed by skin closure. Optimal skin closure is critical as it affects the risk of both cesarean wound infection and dehiscence. To our knowledge, however, no clinical or real-world studies comparing 2OPMT with conventional sutures for skin closure following cesarean delivery have been published to date. We sought to compare the economic and clinical outcomes of cesarean deliveries with skin closure using 2-octyl cyanoacrylate plus polymer mesh tape (2OPMT) versus conventional smooth sutures plus waterproof wound dressings (CS-WWD). METHODS: This was a retrospective, observational study using a database derived from hospital electronic health records and billing data from over 1,000 U.S. hospitals (PINC AI RESULTS: After weighting, the CSWWD ( CONCLUSIONS: In this large observational study, cesarean deliveries with skin closure using 2OPMT were associated with lower post-surgical length of stay, lower total hospital costs for the cesarean delivery stay, lower incidence proportions of 30-day readmissions, and lower incidence proportions of 30-day clinical/wound complications as compared with CS-WWD.