Protein-Ligand Interactions: Target Identification and Drug Discovery

• Tác giả: Fabio Altieri
• Ngôn ngữ: eng
• ISBN-13: 978-3036510507
• Thông tin xuất bản: Basel, Switzerland : MDPI - Multidisciplinary Digital Publishing Institute, 2021
• Mô tả vật lý: 1 electronic resource (184 p.)
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 227898
• Chủ đề: 1. Chemistry; 2. Research & information: general

Tóm tắt

Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials.