Lipoprotein(a) immunoassays and their associations with coronary artery calcification and aortic valve calcification.

• Tác giả: Daniel Bos, Yolanda B de Rijke, Maryam Kavousi, Ching F Khan, Maarten J G Leening, Eric J G Sijbrands, Sunny S Singh, Fang Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.1232 Diseases of cardiovascular system
• Thông tin xuất bản: United States : American heart journal , 2025
• Bộ sưu tập: NCBI
• ID: 229163

Tóm tắt

Lp(a) causes atherosclerosis and degenerative aortic valve disease, but concerns have risen that mass-based assays may be affected by isoform sizes and provide inaccurate estimates of Lp(a) exposure. We compared contemporary immunoturbidimetric assays reporting either mass-based (Randox) or molar-based (Roche) using data from 5129 unselected participants from the prospective population-based Rotterdam Study. We demonstrate that these immunoassays provide interchangeable Lp(a) measurements, and that associations with CT coronary artery calcium and aortic valve calcification were near-identical.