Turning Off STAT6 with a Targeted Degrader.

• Tác giả: Dehua Pei
• Ngôn ngữ: eng
• Ký hiệu phân loại: 354.6 Administration of construction, manufacturing, service industries
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 229281

Tóm tắt

While an attractive target for treating a range of human diseases and conditions, signal transducer and activator of transcription 6 (STAT6) has resisted drug discovery efforts for decades. This Viewpoint summarizes the discovery of a highly potent, selective STAT6 degrader with minimal off-target activity.