Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

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Tác giả: Blanca Rodriguez, Eleonora Grandi, Esther Pueyo, Stefano Morotti

Ngôn ngữ: eng

ISBN-13: 978-2889455393

Ký hiệu phân loại:

Thông tin xuất bản: Frontiers Media SA, 2018

Mô tả vật lý: 1 electronic resource (385 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 229300

Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.
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