Granulomatous mastitis is an unknown disease for the plastic surgeon, it is frequent, benign and can be confused with an infectious process and its importance lies in the fact that it can occur after surgery. Its diagnosis is clinical, presenting an indurated region in the breast, which can progress to abscesses or crypts, as well as radiological and histological. We present the case of a 57-year-old patient who presented with a lesion 1 month after a reduction mammoplasty. Conservative treatment was carried out with the possibility of fat necrosis and due to persistence, granulomatous mastitis was confirmed by biopsy after 6 months of evolution. This article establishes a diagnostic and treatment protocol based on the latest recommendations in the literature, oriented towards plastic surgery, starting with oral steroids in long courses, and immunomodulators may be used for resistant cases, including excisional surgical management. In the case of abscesses or crypts, treatment of the concomitant infection should be given.