Electrospun and Electrosprayed Formulations for Drug Delivery

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Tác giả: Ian S Blagbrough, Gareth R Williams

Ngôn ngữ: eng

ISBN-13: 978-3038979128

ISBN-13: 978-3038979135

ISBN: books9783038979135

Ký hiệu phân loại: 615.19 Pharmaceutical chemistry

Thông tin xuất bản: MDPI - Multidisciplinary Digital Publishing Institute, 2019

Mô tả vật lý: 1 electronic resource (190 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 230829

 This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers
  ferulic acid solid dispersions
  electrospun medicines to treat psoriasis
  scale up of electrospinning and its use to produce low-dose tablets
  transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
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