Asymmetric Catalytic Aziridination to Synthesize Spiro-aziridine Oxindoles.

• Tác giả: Xiaoming Feng, Xiaohua Liu, Zhenzhong Liu, Yinhe Qu, Yuqiao Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Chemistry (Weinheim an der Bergstrasse, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 231212

Tóm tắt

 Asymmetric catalytic aza-Michael-initiated ring closure of methyleneindolinones with N-tosyloxycarbamates has been established. The reaction using a chiral nickel complex catalyst enabled the formation of a series of spiro-aziridine oxindoles in good yields (up to 99%) with high stereoselectivity (up to 97% ee, >
 19:1 dr) under mild reaction conditions. Ring-opening of spiro-aziridine oxindole leads to formation of glycinate-bearing oxindoles with retention of configuration.