The book is dealing with recent progress in human-computer interaction (HCI) related to geographic information science (GIS). The Editorial starts with an overview about the evolution of the Internet and first HCI concepts and stimulates recent HCI developments using 3D and 4D apps, running on all mobile devices with OS Android, iOS, Linus, and Windows. Eight research articles present the state-of-the-art in HCI-GIS-related issues, starting with gender and age differences in using indoor maps via the estimation of building heights from space to an efficient visualization method for polygonal data with dynamic simplification. The review article deals with progress and challenges on entity alignment of geographic knowledge bases.