Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.

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Tác giả: Meredith E K Calvert, Darren Chan, Roni Chau, Kylie S Chew, Johann Chow, Allisa Clemens, Gabrielly L De Melo, Claire B Discenza, Jason C Dugas, Joseph Duque, Ali Ertürk, Connie Ha, David Joy, Doris Kaltenecker, Holly Kane, Nathalie Khoury, Amy Leung, Joseph W Lewcock, Edwin Lozano, Arash Moshkforoush, Moritz Negwer, Michelle E Pizzo, Yaneth Robles-Colmenares, Elysia Roche, Thomas Sandmann, Lily Sarrafha, Matthew J Simon, David Tatarakis, Robert G Thorne, Mihail Ivilinov Todorov, Mabel Tong, Kaitlin Xa, Y Joy Yu Zuchero, Yinhan Zhou

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Nature communications , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 231723

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Blood brain barrier-crossing molecules targeting transferrin receptor (TfR) and CD98 heavy chain (CD98hc) are widely reported to promote enhanced brain delivery of therapeutics. Here, we provide a comprehensive and unbiased biodistribution characterization of TfR and CD98hc antibody transport vehicles (ATV

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