Advances in reactor designs, materials and human-machine interfaces guarantee safety and reliability of emerging reactor technologies, eliminating possibilities for high-consequence human errors as those which have occurred in the past. New instrumentation and control technologies based in digital systems, novel sensors and measurement approaches facilitate safety, reliability and economic competitiveness of nuclear power options. Autonomous operation scenarios are becoming increasingly popular to consider for small modular systems. This book belongs to a series of books on nuclear power published by InTech. It consists of four major sections and contains twenty-one chapters on topics from key subject areas pertinent to instrumentation and control, operation reliability, system aging and human-machine interfaces. The book targets a broad potential readership group - students, researchers and specialists in the field - who are interested in learning about nuclear power.