As suggested by the title of this Special Issue, liquid chromatography-mass spectrometry plays a pivotal role in the field of proteomics. Indeed, the research and review articles 
published in the Issue clearly evidence how the data produced by this sophisticated methodology may promote impressive advancements in this area. From among the topics discussed in the Issue, a few point to the development of 
new procedures for the 
optimization of the experimental conditions that should be applied 
for the identification of proteins present in complex mixtures. 
Other applications 
described in these articles show 
the huge potential of 
these strategies in the protein profiling of organs and 
range from 
to the study of post-translational tissue modifications to the investigation of the molecular mechanisms behind human disorders and the identification of potential biomarkers of these diseases.