The highly uncertain evolution of the COVID-19 pandemic, influenced in part by government actions, social behavior, and vaccine-related developments, will play a critical role in shaping the global recovery's strength and durability. This paper develops a modeling approach to embed pandemic scenarios and the rollout of a vaccine in a macroeconometric model and illustrates the impact of different pandemic- and vaccine-related assumptions on growth outcomes. The pandemic and the measures to contain it, including vaccine deployment, are assumed to be represented by consumption shocks in a macroeconometric model. In the baseline scenario, social distancing and a gradual vaccination process allow policy makers to make significant inroads in containing the pandemic. In a downside scenario, insufficient pandemic control efforts accompanied by delayed vaccination leads to persistently higher infection levels and a materially worse growth outcome. In contrast, in an upside scenario, effective management of the pandemic combined with rapid vaccine deployment would set the stage for stronger growth outcomes.