Regulation of Chemokine- Receptor Interactions and Functions

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Tác giả: Martin J. Stone (Ed.)

Ngôn ngữ: eng

ISBN-13: 978-3038427278

Ký hiệu phân loại:

Thông tin xuất bản: Basel, Switzerland : MDPI - Multidisciplinary Digital Publishing Institute, 2018

Mô tả vật lý: 1 electronic resource (228 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 232092

 A hallmark of inflammation is the accumulation of leukocytes, which can serve to remove pathogens and necrotic tissue, but may also damage healthy tissue and exacerbate the inflammatory response. Our understanding of leukocyte recruitment in inflammation was revolutionized in the late 1980s by the discovery of chemokines (chemotactic cytokines), a family of small, secreted proteins that induce migration of selective subsets of leukocytes. Shortly afterwards, chemokines were found to exert their functions through the now familiar chemokine receptors, members of the G protein-coupled receptor superfamily. As their physiological and pathological functions were elucidated, chemokine receptors have become popular targets for drug development in inflammatory diseases as well as cancer metastasis and HIV infection. Extensive research has revealed that the functions of chemokines and their receptors are regulated at numerous levels, including: genetic mutations/polymorphisms
  control of expression levels
  ligand internalization via functional or decoy receptors
  intrinsic selectivity of chemokine-receptor binding
  hetero- or homo-oligomerization of chemokines or of receptors
  alternative signalling pathways
  interaction of chemokines with glycosaminoglycans
  post-translational modifications
  and binding to pathogen-derived inhibitors. This Special Issue of IJMS focused on the natural and pharmacological mechanisms by which the activities of chemokines and their receptors can be regulated.
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