OBJECTIVE: We aimed to characterize general movements in neonates with congenital gastrointestinal anomalies and to compare them to general movements in extremely low birth weight (ELBW) infants. STUDY DESIGN: This was a retrospective, single-site study. Subjects were divided into two groups: those with gastrointestinal (GI) anomalies and ELBW infants (birth weight <
1 kg). The primary outcome was general movement assessments. RESULT: Ninety-six infants were included (n = 51, GI group and n = 45, ELBW group). The rates of abnormal general movements between the groups were comparable (writhing movements: 61% vs. 59%, p = 0.89
fidgety movements: 20% vs. 36%, p = 0.13). Writhing movements were different (100% poor repertoire, 0% cramped synchronous in the GI group vs. 50% poor repertoire and 50% cramped synchronous in the ELBW group, p <
0.001). CONCLUSION: Infants with gastrointestinal anomalies are at risk for abnormal general movements. Abnormal fidgety general movements may be an early biomarker for future motor deficits.