Spectrally Resolved Single-Molecule Orientation Imaging Reveals a Direct Correspondence between the Polarity and Microviscosity Experienced by Nile Red in Supported Lipid Bilayer Membranes.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Manoj Kumbhakar, Jyotsna Bhatt Mitra, Vinu Namboodiri, Aranyak Sarkar, Veerendra K Sharma

Ngôn ngữ: eng

Ký hiệu phân loại: 621.3822 Electrical, magnetic, optical, communications, computer engineering; electronics, lighting

Thông tin xuất bản: United States : The journal of physical chemistry. B , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 233539

Molecular-level interactions among lipids, cholesterol, and water dictate the nanoscale membrane organization of lipid bilayers into liquid-ordered (Lo) and liquid-disordered (Ld) phases, characterized by different polarities and orders. Generally, solvatochromic dyes easily discriminate polarity difference between Lo and Ld phases, whereas molecular flippers and rotors show distinct photophysics depending on the membrane order. Despite progress in single-molecule spectral imaging and single-molecule orientation mapping, direct experimental proof linking polarity with microviscosity sensed by the same probe eludes us. Here, we demonstrate spectrally resolved single-molecule orientation localization microscopy to connect nanoscopic localization of a probe on a bilayer membrane with its emission spectra, three-dimensional dipole orientation, and rotational constraint offered by the local microenvironment and highlight the excellent correspondence between the polarity and order experienced by the same probe. This technique has the potential to address nanoscale heterogeneity and dynamics, especially in biology and material sciences.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH