PET Imaging of PD-L1 Occupancy for Preclinical Assessment of the Efficacy of Combined Anti-PD-L1 Immunotherapy and Targeted Therapy.

• Tác giả: Alizée Bouleau, Céline Chevaleyre, Steven Dubois, Dimitri Kereselidze, Bernard Maillère, Hervé Nozach, Hélène Quelquejay, Simon Specklin, Nicolas Tournier, Charles Truillet, Léa Zimmermann
• Ngôn ngữ: eng
• Ký hiệu phân loại: 020.683 Personnel management (Human resource management)
• Thông tin xuất bản: United States : Journal of nuclear medicine : official publication, Society of Nuclear Medicine , 2025
• Bộ sưu tập: NCBI
• ID: 233620
• Chủ đề: 1. Pet; 2. Imaging; 3. Of

Tóm tắt

The development of resistance significantly hampers the efficacy of immunotherapies in cancer treatment. The combination of JQ1, a BRD4 protein inhibitor, and anti-programmed death ligand 1 (PD-L1) immunotherapies has a synergic therapeutic potential to treat solid tumors. This study aimed to evaluate the potential of immuno-PET imaging for measuring pharmacodynamic biomarkers in response to this combination therapy targeting PD-L1.