Large-scale proteomic analyses of incident Parkinson's disease reveal new pathophysiological insights and potential biomarkers.

• Tác giả: Wei Cheng, Qiang Dong, Jian-Feng Feng, Yi-Han Gan, Yu Guo, Xiao-Yu He, Yu He, Yu-Zhu Li, Ling-Zhi Ma, Lin-Bo Wang, Jia You, Jin-Tai Yu, Yi Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 003.71 Large-scale systems
• Thông tin xuất bản: United States : Nature aging , 2025
• Bộ sưu tập: NCBI
• ID: 233882

Tóm tắt

The early pathophysiology of Parkinson's disease (PD) is poorly understood. We analyzed 2,920 Olink-measured plasma proteins in 51,804 UK Biobank participants, identifying 859 incident PD cases after 14.45 years. We found 38 PD-related proteins, with six of the top ten validated in the Parkinson's Progression Markers Initiative (PPMI) cohort. ITGAV, HNMT and ITGAM showed consistent significant association (hazard ratio: 0.11-0.57, P = 6.90 × 10