Extracellular vesicle-mediated gene therapy targets BRAF

• Tác giả: Liang Chen, Ziye Guo, Donghua Huang, Xin Liu, Jisheng Ran, Di Wang, Liwei Wang, Kaile Wu, Jianbin Xu, Kaicheng Xu, Minjun Yao, Chenyi Ye, Wei Zhang, Yubin Zhao, Liming Zheng, Wei Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.2833 Motor land vehicles, cycles
• Thông tin xuất bản: England : Journal of nanobiotechnology , 2025
• Bộ sưu tập: NCBI
• ID: 234820

Tóm tắt

BACKGROUND: Patients with colorectal cancer (CRC) harboring BRAF mutation have a poor prognosis. The median survival time for patients with advanced BRAF AIM: This study aims to develop a precise therapeutic system for BRAF METHOD: We first obtained engineered cells capable of stably producing EVs loaded with BRAF RESULT: EVs-siBRAF CONCLUSION: The therapeutic EVs we constructed are effective and specific for the BRAF