Efficacy of the neurotensin receptor 1 analog PD149163 in modulation of the kidney inflammation: Inhibition of the nuclear factor kappa β signaling pathway and oxidative stress in endotoxemic mice.

• Tác giả: Swarnima Mishra, Banalata Mohanty, Sonia Srivastava
• Ngôn ngữ: eng
• Ký hiệu phân loại: 972.8202 *Central America
• Thông tin xuất bản: Netherlands : European journal of pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 234942

Tóm tắt

 This study elucidated that the neurotensin receptor 1 agonist PD149163 ameliorated the kidney inflammation in endotoxemic mice inhibiting the nuclear factor kappa β (NF-kβ) pathway and reducing the oxidative stress in a dose-dependent manner. Swiss albino female mice (8 weeks
  25±5 gms) were maintained in six groups (n=6): Group 1/control, Group 2, Group 3 and Group 4 were exposed to lipopolysaccharide/LPS (1mg/kg bw
  i.p
  5 days) followed by PD149163 treatment with low dose/NT